SCH 336

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SCH 336

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

447459-51-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

SCH-225336

产品介绍

SCH 336 是一种有效的、选择性的、反向的和具有口服活性的CB2激动剂。SCH 336 抑制 BaF3/CB2 细胞迁移。SCH 336 显着抑制体内白细胞的迁移。SCH 336 可阻断卵白蛋白诱导的小鼠肺嗜酸性粒细胞增多。

生物活性

SCH 336 is a potent, selective, inverse and orally activeCB2agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice^[1].

IC₅₀& Target^[1]

hCB2-R

体外研究
(In Vitro)

SCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with K_iof 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC₅₀of 2 nM, decreases potency on CB1-containing membranes with EC₅₀of 200 nM^[1].
SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC₅₀of 34 nM^[1].

体内研究
(In Vivo)

SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes^[1].

Animal Model:	Female B6D2/F1 mice (HU210)^[1]
Dosage:	0.02, 0.2, 2.0 mg/kg
Administration:	I.p.
Result:	Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.

分子量

539.64

Formula

C₂₃H₂₅NO₈S₃

CAS 号

447459-51-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.