CCR4 antagonist 3-1

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CCR4 antagonist 3-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1957-01-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CCR4 antagonist 3 是一种有效的趋化因子受体 4 (CCR4) 拮抗剂，对 [¹²⁵I]TARC (胸腺和活化调节趋化因子) 的IC₅₀为 1.7 μM。CCR4 antagonist 3 可抑制 CEM 细胞表面 [¹²⁵I]TARC和巨噬细胞来源的趋化因子 (MDC) 与 CCR4 受体的结合。CCR4 antagonist 3 也能在体外抑制 TARC 介导的 CEM 细胞迁移 (IC₅₀=6.4 μM)。

生物活性

CCR4 antagonist3 is a potentchemokine receptor4 (CCR4)antagonist with anIC₅₀value of 1.7 μM for [¹²⁵I]TARC (thymus and activation regulated chemokine).CCR4 antagonist3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) toCCR4receptors on the surface of CEM cells.CCR4 antagonist3 also inhibits thein vitromigration of CEM cells mediated by TARC (IC50 = 6.4 μM)^[1].

IC₅₀& Target^[1]

CCR4	[¹²⁵I]-TARC-CCR4 1.7 μM (IC₅₀)

体内研究
(In Vivo)

CCR4 antagonist 3 (compound 1) (0.5 mg/kg for IV; 2 mg/kg for PO; single dosage) exhibits a high clearance, short half-life and low oral bioavailability^[1].

Animal Model:	Rats^[1]
Dosage:	0.5 mg/kg for IV; 2 mg/kg for PO
Administration:	IV and PO; single dosage
Result:	Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%.

分子量

240.32

Formula

C₁₄H₁₂N₂S

CAS 号

1957-01-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.