JNJ-26070109

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JNJ-26070109

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

844645-08-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JNJ-26070109 是一种高亲和力、竞争性、口服有效的选择性胆囊收缩素 2 (CCK2) 受体拮抗剂，pK_i分别为 8.49、7.99 , 和 7.70 分别用于人类、大鼠和狗 CCK2 受体。JNJ-26070109具有良好的药代动力学特性。CCK2 受体在调节胃酸分泌和胃肠黏膜生长方面的双重功能使其成为治疗胃食管反流病的有吸引力的新靶点。

生物活性	JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selectivecholecystokinin 2(CCK2) receptor antagonist with good pharmacokinetic properties, withpK_is of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the treatment of gastroesophageal reflux disease^[1].
IC₅₀& Target	pK_i: 8.49 (human CCK2), 7.99 (rat CCK2), 7.70 (dog CCK2)^[1]
分子量	547.37
Formula	C₂₃H₁₇BrF₂N₄O₃S
CAS 号	844645-08-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.