Rutaecarpine, an alkaloid ofEvodia rutaecarpa, is an inhibitor ofCOX-2with anIC₅₀value of 0.28 μM.

Rutaecarpine has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems^[2]. Rutaecarpine inhibits COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC₅₀of 0.28 μM and 8.7 μM, respectively. It inhibits COX-2-dependent conversion of exogenous arachidonic acid to PGE₂in a dose-dependent manner by the COX-2-transfected HEK293 cells^[1].

Rutaecarpine showedin vivoanti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration^[1]. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine^[3].

287.32

Solid

C₁₈H₁₃N₃O

84-26-4

吴茱萸次碱

• Alkaloids
• Indole Alkaloids

• Plants
• Rutaceae
• Evodia rutaecarpa(Juss.) Benth.

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL(174.02 mM;Need ultrasonic)

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