COX-2-IN-21 (Compound 5c) is a selective and orally activeCOX-2inhibitor with anIC₅₀of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential^[1].

COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib^[1].
COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE₂greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib^[1].

422.44

C₂₁H₂₂N₆O₄

2519631-11-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.