Hydrangenol 是一种口服有效的抗光老化化合物。可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 通过降低MMP和炎症细胞因子的表达，增加保湿因子和抗氧化基因的水平来预防皱纹的形成。
| 生物活性 | Hydrangenol is an orally active antiphotoaging compound. It can be isolated fromHydrangea serrataleaves. Hydrangenol prevents wrinkle formation by reducingMMPand inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1]. |
| IC50& Target[1] | |
体内研究
(In Vivo) | Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。
| Animal Model: | UVB-irradiated HR-1 hairless mice[1] | | Dosage: | 5, 10, 20, or 40 mg/kg | | Administration: | Oral gavage; daily for 7 weeks | | Result: | Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation.
Increased the expression of Pro-COL1A1.
Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).
Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).
Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC). |
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| 结构分类 | - Phenylpropanoids
- Coumarins
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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