Glucocorticoid receptor-IN-2 (Compound WX019) is a selectiveglucocorticoid receptor(GR)modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with anIC₅₀of 0.171 nM againsthMMP1, and comparable transcriptional activation activity with anEC₅₀of 0.94 nM againstMMTV^[1].

Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC₅₀of 0.98 nM^[1].
Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC₅₀of 9.12 μM^[1].

512.46

C₂₅H₂₀F₄N₆O₂

2664932-65-2

Room temperature in continental US; may vary elsewhere.

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