ORIC-101

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ORIC-101

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2222344-98-9

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

ORIC-101 是一种有效、选择性的糖皮质激素受体 (glucocorticoid receptor) 拮抗剂，EC₅₀值为 5.6 nM。抗癌作用。

生物活性

ORIC-101 is a highly potent and selectiveglucocorticoid receptorantagonist, with anEC₅₀of 5.6 nM. Anti-cancer activity.

IC₅₀& Target

EC50: 5.6 nM (Glucocorticoid receptor)^[1]

体外研究
(In Vitro)

ORIC-101 shows markedly reduced androgen receptor agonism (EC₅₀, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC₅₀, >10 μM)^[1].
ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC₅₀s of 17.2 and 21.2 nM, respectively^[1].

体内研究
(In Vivo)

ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice^[1].

Animal Model:	OVCAR5 xenograft tumor in cortisol-treated mice^[1]
Dosage:	75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin
Administration:	P.O. twice a day for 16-22 days
Result:	Significantly reduced tumor volume in combination with chemotherapeutic agents.

Clinical Trial

分子量

501.74

性状

Solid

Formula

C₃₄H₄₇NO₂

CAS 号

2222344-98-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(199.31 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9931 mL	9.9653 mL	19.9306 mL
5 mM	0.3986 mL	1.9931 mL	3.9861 mL
10 mM	0.1993 mL	0.9965 mL	1.9931 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。