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Cimetidine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cimetidine hydrochloride图片
CAS NO:70059-30-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SKF-92334 hydrochloride
产品介绍
Cimetidine (SKF-92334) hydrochloride 是一种具有口服活性的,可逆的组胺H2受体拮抗剂,Ki为 0.6 μM。Cimetidine hydrochloride 是一种胃酸减少剂,可用于十二指肠和胃溃疡研究。Cimetidine hydrochloride 具有抗癌和抗炎活性。
生物活性

Cimetidine (SKF-92334) hydrochloride is an orally active and inversehistamine H2 receptorantagonist with aKiof 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity[1][2][5].

IC50& Target[1]

H2Receptor

 

H2Receptor

0.6 μM (Kd)

体外研究
(In Vitro)

Cimetidine (SKF-92334) hydrochloride, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine hydrochloride has no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells)[3].
Cimetidine hydrochloride shows no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine hydrochloride reverses MDSC-mediated T-cell suppression, and improves IFN-γ production[4].
Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression[5].

体内研究
(In Vivo)

Cimetidine (SKF-92334) hydrochloride reduces CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice[4].
Cimetidine hydrochloride exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption[6].

Clinical Trial
分子量

288.80

Formula

C10H17ClN6S

CAS 号

70059-30-2

中文名称

盐酸西咪替丁;盐酸甲氰咪胍;盐酸甲氰咪胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.