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Delmitide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Delmitide图片
CAS NO:287096-87-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
RDP-58
产品介绍
Delmitide (RDP58) 是一种 具有有效的抗炎活性的 d-异构体十肽,具有口服活性。Delmitide 抑制 TNF-α、IFN-γ 和白细胞介素 (IL)-12 的产生,并上调血红素加氧酶 1 的活性。Delmitide 可用于溃疡性结肠炎的研究。
生物活性

Delmitide (RDP58) is an orally active d-isomer decapeptide with potentanti-inflammatoryactivity. Delmitide inhibits production of TNF-α,IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis[1][2].

体内研究
(In Vivo)

Delmitide (oral; 2.5, 5, 10 mg/kg; daily) significantly reduced CPT-11induced diarrhea, mucosal inflammation, and mortality in mice by suppressing the overproduction of proinflammatory cytokines TNF-a, IFN-y, and IL-12 in vivo[2].
Delmitide (oral; 2.5, 5, 10 mg/kg; daily) generates an enhanced tumor response and prolongation of time to relapse without concomitant Gl toxicity in mice[2].

Animal Model:BALB/c mice (female, 9-10-week)[2]
Dosage:2.5, 5, 10 mg/kg or 0.2 mL, 10 mg/kg
Administration:Oral, daily
Result:Reduced the incidence of diarrhea and attenuated CPT-11-associated GI toxicity and mortality in a dose-dependent manner.
Had protective effect against chemotherapy-induced GI side-effects and reduced CPT-11-induced overexpression of TNF-α, IFN-γ, and IL-12 in vivo.
Preserved the intestinal mucosa morphology by maintaining villus and crypt structure and inhibited TNF-α-mediated apoptosis in the crypt compartment, thereby protecting intestinal mucosa integrity in mice.
Protected mice from CPT-11-induced GI toxicity and mortality and enhanced animal survival in tumor-bearing mice.
Significantly reduced the incidence and overall tumor burden in a spontaneously metastatic model.
分子量

1228.57

Formula

C59H105N17O11

CAS 号

287096-87-1

Sequence Shortening

D(R-Nle-Nle-Nle-R-Nle-Nle-Nle-GY-NH2)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.