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2',3'-cGAMP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2',3'-cGAMP图片
CAS NO:1441190-66-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
2'-3'-cyclic GMP-AMP
产品介绍
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是一种哺乳动物细胞中的内源性 cGAMP。2',3'-cGAMP 以高亲和力结合STING,是干扰素-β (IFNβ) 的有效诱导物。2',3'-cGAMP 是在哺乳动物细胞中为响应细胞质中的 DNA 而产生。
生物活性

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds toSTINGwith a high affinity and is a potent inducer ofinterferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

分子量

674.41

Formula

C20H24N10O13P2

CAS 号

1441190-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

H2O : 5 mg/mL(7.41 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.4828 mL7.4139 mL14.8278 mL
5 mM0.2966 mL1.4828 mL2.9656 mL
10 mM---------