ODN D-SL03

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ODN D-SL03

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1198621-85-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

ODN D-SL03 是一种 C 类 CpG 寡核苷酸，可诱导刺激 PBMCs 产生高水平IFN-α。ODN D-SL03 可激活人 B 细胞、NK 细胞和单个核细胞，上调人 PBMCs 亚群表面 CD80、CD86 和 HLA-DR 的表达。ODN D-SL03 也能抑制肿瘤的生长。ODN D-SL03 序列：5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'。

生物活性

ODN D-SL03 is a C class CpGoligonucleotides, can induce stimulate PBMCs to produce high level ofIFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'^[1].

IC₅₀& Target

IFN-α^[1]

体外研究
(In Vitro)

ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL^[1].
ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells^[1].

体内研究
(In Vivo)

ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth^[1].

Animal Model:	Female BALB/c mice (6-8 weeks; inoculated with 5×10⁵EMT6 cells)^[1]
Dosage:	25 μg per mouse
Administration:	Peritumoral injection, six times in one-day interval, for 0-100 days
Result:	Induced significant inhibition of tumor growth.

分子量

9345.00

性状

Solid

CAS 号

1198621-85-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)