CAS NO: | 339303-87-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | GP130 receptor agonist-1 is a potent, brain-penetrant and orally activeGP130 receptoragonist. GP130 receptor agonist-1 has a neuroprotective effect on NMDA-induced neurotoxicity[1]. | ||||||||||||||||
体外研究 (In Vitro) | In SH-SY5Y cells, GP130 receptor agonist-1 (Compound 2) treatment showed a 2-fold increase in phosphorylation of STAT3 within 10 min at its regulatory Tyr705 site. In primary hippocampal neuronal cultures, the pSTAT3 levels are below levels of detection for GP130 receptor agonist-1 at all time points[1]. | ||||||||||||||||
体内研究 (In Vivo) | For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ~4:1 for oral 30 mg/kg and ~7.5:1 for 10 mg/kg SQ injection[1]. | ||||||||||||||||
分子量 | 270.32 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H11FN2S | ||||||||||||||||
CAS 号 | 339303-87-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(369.93 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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