| CAS NO: | 2375835-91-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 生物活性 | Lusvertikimab (OSE-127) is a humanizedIL7Rmonoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research[1]. | |
| IC50& Target[1] |
| |
| 体外研究 (In Vitro) | OSE-127 (4 天) 可阻断 IL7 依赖性 ALL 细胞系和患者来源的异种移植 (PDX) 样本中的 STAT5 磷酸化[2]。 | |
| 体内研究 (In Vivo) | 当相应的对照小鼠显示出明显白血病的临床症状时，OSE-127 处理的小鼠体内 21/22 (95%) PDX 样本显示外周血 (PB) 母细胞减少[1]。 | |
| CAS 号 | 2375835-91-7 | |
| 中文名称 | 芦维奇单抗 | |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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