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EGFR kinase inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EGFR kinase inhibitor 1图片
CAS NO:2413958-04-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
EGFR kinase inhibitor 1 是一种有效的EGFR抑制剂,对 WT, l885R/T790M, L858R/T790M/C797S 的IC50分别为 37、1.7、>300 nM。EGFR kinase inhibitor 1 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。EGFR kinase inhibitor 1 抑制细胞转移。EGFR kinase inhibitor 1 具有抗增殖和抗肿瘤活性。
生物活性

EGFRkinase inhibitor 1 is a potentEGFRinhibitor withIC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively.EGFRkinase inhibitor 1 inducesapoptosisand cell cycle arrest at G0/G1-phase.EGFRkinase inhibitor 1 inhibits the cell motility.EGFRkinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].

IC50& Target[1]

EGFR (WT)

37 nM (IC50)

EGFRL858R/T790M

1.7 nM (IC50)

EGFRL858R/T790M/C797S

>300 nM (IC50)

体外研究
(In Vitro)

EGFR kinase inhibitor 1 (compound 17i) (72 h) shows antiproliferative activity withIC50s of 4.17, 0.052 μM for A549, H1975 cells, respectively[1].
EGFR kinase inhibitor 1 (0.05, 0.5, 5 μM; 48 h) induces apoptosis in a dose-dependent manner[1].
EGFR kinase inhibitor 1 (4, 20, 100 nM; 48 h) induces cell cycle arrest at G0/G1-phase[1].
EGFR kinase inhibitor 1 (0.5 μM; 0, 24, 48 h) inhibits the motility of the H1975 cells[1].

Cell Cytotoxicity Assay[1]

Cell Line:A549, H1975 cells
Concentration:
Incubation Time:72 h
Result:Showed antiproliferation activity withIC50s of 4.17, 0.052 μM for A549, H1975 cells, respectively.

Apoptosis Analysis[1]

Cell Line:H1975 cells
Concentration:0.05, 0.5, 5 μM
Incubation Time:48 h
Result:Induced apoptosis in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line:H1975 cells
Concentration:4, 20, 100 nM
Incubation Time:48 h
Result:Induced cell cycle arrest at G0/G1-phase with the percentage of G0/G1-phase cells increased from 42.93% to 60.52% at 4 nM, 70.39% at 20 nM and 80.03% at 100 nM.
分子量

521.61

Formula

C30H31N7O2

CAS 号

2413958-04-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.