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HER2-IN-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HER2-IN-9图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
HER2-IN-9 是一种具有口服活性的HER2抑制剂,IC50值为0.03 μM。HER2-IN-9 抑制 HER-2 阳性的乳腺癌细胞增殖和迁移。HER2-IN-9 可用于乳腺癌研究。
生物活性

HER2-IN-9 is an orally activeHER2inhibitor, with anIC50value of 0.03 μM. HER2-IN-9 inhibits HER-2 positive breastcancercells proliferation and migration. HER2-IN-9 can be used in the research of breast cancers[1].

IC50& Target[1]

HER2

0.03 μM (IC50)

体外研究
(In Vitro)

HER2-IN-9 (24 h) shows anti-proliferation activities against cancer cells (A549, HEPG2, MCF7, SKBR3)[1].
HER2-IN-9 (0-60 nM, 24 h) inhibits the migration of SKBR3 cells[1].
HER2-IN-9 (0-60 nM, 24 h) increases E-cadherin levels and decreases N-cadherin levels in SKBR3 cells[1].
HER2-IN-9 (0-60 nM, 24 h) suppresses the expression of p-HER-2, further inhibits the activation of the EMT signal pathway to inhibit the migration of SKBR3 cells[1].

Cell Proliferation Assay[1]

Cell Line:Cancer cells (A549, HEPG2, MCF7, SKBR3), normal cells (Beas2b, LO2, MCF-0A)
Concentration:0.05-30 μM approximately
Incubation Time:24 h
Result:Inhibited cancer cell proliferation with IC50s of 0.05-12.17 μM.
Inhibited noamal cell proliferation with IC50s of 15.4- 26.95 μM.

Western Blot Analysis[1]

Cell Line:SKBR3 cells
Concentration:0, 20, 40, 60 nM
Incubation Time:24 h
Result:Inhibited HER-2 phosphorylation with no significant change in total HER-2 protein levels.
Down-regulated β-catenin, snail, and Vimentin level.
体内研究
(In Vivo)

HER2-IN-9 (oral administration, 30 mg/kg, every two days) inhibits tumor growth SKBR3 orthotopic xenograft model[1].

Animal Model:SKBR3 orthotopic xenograft model[1]
Dosage:30 mg/kg
Administration:Oral administration, every two days.
Result:Inhibited the growth of cancer cellsin vivowithout noticeable toxic effects.
Increased the level of cleaved-caspase 3 implicated in cell death pathways (immunohistochemistry assay in tumor).
分子量

423.23

Formula

C19H14BrF3N2O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.