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Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine图片
CAS NO:2249935-19-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 是一种免疫刺激物抗体偶联物 (ISAC),包含抗人表皮生长因子受体 2 (HER2) 抗体、STING激动剂 (ADU- S100) 和一个连接子。Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 可用于癌症研究 (WO2018200812A1; example 5)。
生物活性

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising ananti-human epidermal growth factor receptor 2 (HER2)antibody, aSTINGagonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd forcancerresearch (WO2018200812A1; example 5)[1].

IC50& Target[1]

HER2

 

体外研究
(In Vitro)

STING (stimulator of interferon genes) is an endoplasmic reticulum adaptor that facilitates innate immune signaling. It was reported that STING comprises four putative transmembrane regions, predominantly resides in the endoplasmic reticulum and is able to activate NF-kB, STAT6, and IRF3 transcription pathways to induce expression of type I interferon (e.g., IFN-a and IFN-β) and exert a potent anti-viral state following expression. In contrast, loss of STING rendered murine embryonic fibroblasts extremely susceptible to negative stranded virus infection, including vesicular stomatitis virus[1].

Formula

C51H65N17O19P2S2.xC6H15N

CAS 号

2249935-19-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.