CAS NO: | 2538149-57-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PDE5-IN-3 (compound 11j) is a potentPDE5inhibitor with anIC50of 1.57 nM. PDE5-IN-3 shows moderateEGFRinhibition with IC50of 5.827 μM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL). PDE5-IN-3 induces the intrinsicapoptoticmitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity[1]. | ||
IC50& Target[1] |
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体外研究 (In Vitro) | PDE5-IN-3 lowers the expression levels of the anti-apoptotic Bcl-2 protein, and causes the high expression of the pro-apoptotic protein Bax, p53, cytochrome c and up-regulates active caspase-9 and caspase-3 levels[1]. | ||
分子量 | 448.27 | ||
Formula | C21H14BrN5O2 | ||
CAS 号 | 2538149-57-2 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |