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PROTAC EGFR degrader 5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PROTAC EGFR degrader 5图片
CAS NO:2409793-36-6
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PROTAC EGFR degrader 5 (Compound 10) 是一种PROTAC EGFR降解剂，可有效降解 HCC827 细胞中的 EGFRDel19，DC50为 34.8 nM。PROTAC EGFR degrader 5 显著诱导 HCC827 细胞凋亡 (apoptosis) 并将细胞阻滞在 G1 期。
生物活性

PROTACEGFR degrader 5 (Compound 10), aPROTACEGFRdegrader, potently degradesEGFRDel19in HCC827 cells with theDC50of 34.8 nM.PROTACEGFR degrader 5 significantly induces theapoptosisof HCC827 cells and arrest the cells in G1 phase[1].

IC50& Target

EGFR

34.8 nM (DC50)

体外研究
(In Vitro)

PROTAC EGFR degrader 5 (PROTAC 10, 0-10 μM approximately, 72 h) inhibits HCC827 cell (NSCLC cell) proliferation with an IC50value of 0.22 μM[1].
PROTAC EGFR degrader 5 (1 nM-10 μM, 48 h or 4-96 h) concentration-dependently and time-dependently degrades EGFR with a DC50value of 34.8 nM in HCC827 cells[1].
PROTAC EGFR degrader 5 (0.1-1 μM, 36 h) concentration-dependently inhibits EGFR and downstream Akt phosphorylation in HCC827 cells[1].
PROTAC EGFR degrader 5 (0.1-10 μM, 48 h) displays weak degradation activity on EGFR in H1975 and A549 cells[1].
PROTAC EGFR degrader 5 (0.1-1 μM, 32 h) dose-dependently induces the apoptosis of HCC827 cells and arrests the cells in G1 phase[1].

Cell Proliferation Assay[1]

Cell Line:HCC827, H1975, A549, A431
Concentration:0-10 μM approximately
Incubation Time:72 h
Result:Displayed more potent anti-proliferative activity against HCC827 cells than other cells, IC50values: 0.22 μM (HCC827), >10μM (H1975, A549, A431), respectively.

Western Blot Analysis[1]

Cell Line:HCC827 cell
Concentration:1 nM-10 μM
Incubation Time:48h for concentration-dependent assay, 4-96 h for time-dependent assay
Result:Degraded EGFR with a DC50value of 34.8 nM in HCC827 cell in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line:HCC827 cell
Concentration:0.1 μM, 1 μM
Incubation Time:32 h
Result:Induced cell apoptosis in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line:HCC827 cell
Concentration:0.1 μM, 1 μM
Incubation Time:32 h
Result:Induced cell cycle arrest in G1 phase.
分子量

1070.33

Formula

C57H72FN13O5S

CAS 号

2409793-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.