PROTAC EGFR degrader 7

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PROTAC EGFR degrader 7 (compound 13b) 是一种有效的、选择性 CRBN 招募的 PROTACEGFR^L858R/T790M降解剂，其DC₅₀为 13.2 nM。PROTAC EGFR degrader 7 抑制 NCI-H1975 细胞增殖，IC₅₀为 46.82 nM。PROTAC EGFR degrader 7 显著诱导 NCI-H1975 细胞凋亡 (apoptosis) 和 G2/M 期阻滞。PROTAC EGFR degrader 7 具有抗肿瘤活性，可用于非小细胞肺癌 (NSCLC) 研究。

生物活性

PROTACEGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruitingPROTACEGFR^L858R/T790Mdegrader, with aDC₅₀of 13.2 nM.PROTACEGFR degrader 7 inhibits NCI–H1975 cells proliferation, with anIC₅₀of 46.82 nM.PROTACEGFR degrader 7 significantly inducesapoptosisand G2/M phase arrest in NCI–H1975 cell.PROTACEGFR degrader 7 shows antitumor activity, and can be used for non-small cell lungcancer(NSCLC) research^[1].

IC₅₀& Target

EGFR^L858R/T790M

13.2 nM (DC₅₀)

体内研究
(In Vivo)

PROTAC EGFR degrader 7 (compound 13b) (BALB/c mice bearing NCI–H1975 cells, 10 mg/kg, IP, once a day for 24 days) effectively and selectively inhibits NCI–H1975 xenograft tumor growth, with the tumor growth inhibition (TGI%) of 63.7%^[1].

分子量

836.94

Formula

C₄₆H₄₈N₁₀O₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.