CAS NO: | 145915-58-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitiveEGFRinhibitor with anIC50of 0.3 μM. CGP52411 blocks the toxic influx of Ca2+ions into neuronal cells, and dramatic inhibits and reverses the formation ofβ-amyloid (Aβ42)fibril aggregates associated with Alzheimer's disease[1][2]. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | CGP52411 (DAPH; 0-100 μM; 90 minutes; A431 cells) treatment inhibits autophosphorylation and c-src autophosphorylation in vitro in a dose-dependent manner withIC50s of 1 μM and 16 μM, respectively. CGP52411 treatment also shows a concentration-dependent reduction in tyrosine phosphorylation of p185c-erbB2 with anIC50value of 10 μM[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | CGP52411 (3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; oral administration; daily; for 15 days; female BALB/c nude mice) treatment in vivo against xenografts of the A431 and SK-OV-3 tumors, and has antitumor activity[1].
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分子量 | 329.35 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H15N3O2 | ||||||||||||||||
CAS 号 | 145915-58-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(303.63 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |