(Z)-SMI-4a

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(Z)-SMI-4a

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

438190-29-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(Z)-SMI-4a 是一种有效的，选择性的，细胞可渗透的且具有 ATP 竞争性的Pim-1抑制剂，其IC₅₀为 24 μM，K_i为 0.6 μM。(Z)-SMI-4a 还抑制Pim-2(IC₅₀为 100 μM)，并且不显着抑制其他丝氨酸/苏氨酸或酪氨酸激酶。(Z)-SMI-4a 具有抗癌活性。

生物活性

(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitivePim-1inhibitor with anIC₅₀of 24 μM and aK_iof 0.6 μM. (Z)-SMI-4a also inhibitsPim-2(IC₅₀of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity^[1].

IC₅₀& Target^[1]

PIM1

24 μM (IC₅₀)

PIM1

0.6 μM (Ki)

PIM2

100 μM (IC₅₀)

体外研究
(In Vitro)

(Z)-SMI-4a (0.5 μM; 1 hour; HEK-293T cells) treatment attenuates the autophosphorylation of tagged Pim-1 in intact cells^[1].

Western Blot Analysis^[1]

Cell Line:	HEK-293T cells
Concentration:	0.5 μM
Incubation Time:	1 hour
Result:	Caused a dose-dependent reduction in Pim-1-induced 4E-BP1 phosphorylation, with an IC₅₀of approximately 125 nM.

分子量

273.23

Formula

C₁₁H₆F₃NO₂S

CAS 号

438190-29-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.