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TRIFLUOPERAZINE 2HCL(TFP SKF5019)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TRIFLUOPERAZINE 2HCL(TFP SKF5019)图片
CAS NO:440-17-5
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)480.42
FormulaC21H24F3N3S.2HCl
CAS No.440-17-5 (dihydrochloride salt);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 88 mg/mL (183.2 mM)
Water: 96 mg/mL (199.8 mM)
Ethanol: 96 mg/mL (199.8 mM)
SMILESFC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl
SynonymsSKF5019; SKF 5019; SKF-5019; Trifluoperazine hydrochloride; NSC 17474; NSC-17474; NSC17474; Trifluoperazine HCl; Tryptazine dihydrochloride; Trazine;
实验参考方法
In Vitro

In vitro activity: Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1).


In VivoTrifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance.
Animal modelRats
Formulation & DosageN/A
ReferencesEur Neuropsychopharmacol. 2005 Mar;15(2):231-4; J Pharmacol Exp Ther. 1999 Aug;290(2):901-7.