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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea图片
CAS NO:1313019-65-6
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
STAT3-IN-7 是一种 Sorafenib 的衍生物，可有效抑制STAT3的磷酸化。STAT3-IN-7 通过依赖 SHP-1 的STAT3失活诱导细胞凋亡 (apoptosis)，不抑制激酶活性，并具有抗癌作用。
生物活性

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation ofSTAT3. STAT3-IN-7 induces cellapoptosisthrough SHP-1 dependentSTAT3inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects[1].

IC50& Target[1]

p-STAT3

 

体外研究
(In Vitro)

STAT3-IN-7 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].

Cell Viability Assay[1]

Cell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:48 hours
Result:Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.

Apoptosis Analysis[1]

Cell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:36 hours
Result:Induced potent apoptotic activity.

Western Blot Analysis[1]

Cell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:36 hours
Result:Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.
体内研究
(In Vivo)

STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].

Animal Model:Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells[1]
Dosage:10 mg/kg
Administration:Oral gavage; daily; for 28 days
Result:Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.
分子量

431.80

Formula

C21H13ClF3N3O2

CAS 号

1313019-65-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.