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Lidocaine Hydrochloride hydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lidocaine Hydrochloride hydrate图片
CAS NO:6108-05-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Lignocaine hydrochloride hydrate
产品介绍
Lidocaine (Lignocaine) hydrochloride hydrate 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride hydrate 通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine hydrochloride hydrate 是一种酰胺衍生物，可用于研究室性心律失常。
生物活性

Lidocaine (Lignocaine) hydrochloride hydrate inhibitssodium channelsinvolving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation ofMEK/ERKandNF-κBsignaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia[1][2].

IC50& Target[1][2]

ERK

 

NF-κB

 

MEK

 

体外研究
(In Vitro)

Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

Cell Proliferation Assay[2]

Cell Line:The human gastric cancer cell line MKN45
Concentration:10 nM
Incubation Time:48 hours
Result:Decreased significantly cell proliferation.

Cell Viability Assay[2]

Cell Line:The human gastric cancer cell line MKN45
Concentration:1, 5 and 10 nM
Incubation Time:24, 48, 72 hours
Result:Inhibited MKN45 cell viability.

Apoptosis Analysis[2]

Cell Line:The human gastric cancer cell line MKN45
Concentration:10 nM
Incubation Time:48 hours
Result:Increased significantly the apoptotic cell rate.

Western Blot Analysis[2]

Cell Line:The human gastric cancer cell line MKN45
Concentration:10 nM
Incubation Time:48 hours
Result:Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
体内研究
(In Vivo)

Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

Clinical Trial
分子量

288.81

Formula

C14H25ClN2O2

CAS 号

6108-05-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.