JNK3 inhibitor-5

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JNK3 inhibitor-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JNK3 inhibitor-5 (Compound 22b) 是一种有效的、选择性的JNK3抑制剂，其IC₅₀为 0.379 nM。JNK3 inhibitor-5 有效保护神经元细胞免受淀粉样蛋白 β 诱导的凋亡 (apoptosis)。JNK3 inhibitor-5 具有较高的细胞渗透性，预计可渗透血脑屏障。

生物活性

JNK3inhibitor-5 (Compound 22b) is a potent and selectiveJNK3inhibitor with anIC₅₀of 0.379 nM.JNK3inhibitor-5 effectively protects the neuronal cells against amyloid beta-inducedapoptosis.JNK3inhibitor-5 has a high cell permeability and is predicted as BBB permeable^[1].

IC₅₀& Target^[1]

JNK3

0.379 nM (IC₅₀)

JNK2

29.4 nM (IC₅₀)

JNK1

82.7 nM (IC₅₀)

p38α

215.8 nM (IC₅₀)

GSK-3β

3889.7 nM (IC₅₀)

体外研究
(In Vitro)

JNK3 inhibitor-5 (Compound 22b) (10 μM; 24 h) 显示对淀粉样蛋白诱导的细胞凋亡有神经保护作用^[1]。

Cell Viability Assay^[1]

Cell Line:	Primary rat cortical neurons
Concentration:	10 μM
Incubation Time:	Pre-treated for 90 min, followed by treatment with 10 μM Aβ₄₂(HIFP-treated) for 24 h on day 5 of differentiation
Result:	Showed excellent neuroprotective effect.

Western Blot Analysis^[1]

Cell Line:	Primary rat cortical neurons
Concentration:	10 μM
Incubation Time:	90 min
Result:	Highly mitigated Aβ1-42-induced c-Jun phosphorylation.

分子量

395.46

Formula

C₂₀H₂₅N₇O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.