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TOMATIDINE HYDROCHLORIDE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TOMATIDINE HYDROCHLORIDE图片
CAS NO:6192-62-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
盐酸番茄碱
产品介绍
Tomatidine hydrochloride 通过阻断NF-κBJNK信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。
生物活性

Tomatidine hydrochloride acts as an anti-inflammatory agent by blockingNF-κBandJNKsignaling[1]. Tomatidine hydrochloride activatesautophagyeither in mammal cells orC elegans[2].

IC50& Target[1]

p65

 

JNK

 

体外研究
(In Vitro)

Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].

分子量

452.11

性状

Solid

Formula

C27H46ClNO2

CAS 号

6192-62-7

中文名称

盐酸番茄碱

结构分类
  • Steroids
来源
  • Plants
  • Solanaceae
  • Lycopersicon esculentumMiller
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 5 mg/mL(11.06 mM;ultrasonic and adjust pH to 9 with NaOH)

Ethanol : 3.45 mg/mL(7.63 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.2119 mL11.0593 mL22.1185 mL
5 mM0.4424 mL2.2119 mL4.4237 mL
10 mM0.2212 mL1.1059 mL2.2119 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。