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8-Hydroxyefavirenz
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8-Hydroxyefavirenz图片
CAS NO:205754-33-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
8-OH-EFV
产品介绍
8-Hydroxyefavirenz 是 Efavirenz (HY-10572) 的主要代谢物,8-Hydroxyefavirenz 通过 JNK 和 BimEL 依赖机制诱导原代人肝细胞凋亡 (apoptosis)。8-Hydroxyefavirenz 可用于癌症研究。
生物活性

8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite ofEfavirenz(HY-10572). 8-Hydroxyefavirenz inducesapoptosisvia a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research ofcancer[1].

体外研究
(In Vitro)

8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; 原代人肝细胞) 以时间和浓度依赖的方式增加细胞死亡,并从 6 小时开始诱导 caspase-3 活性[1]
8-Hydroxyefavirenz (1-10 μM; 6-24 h) 刺激原代人肝细胞中线粒体 ROS 的产生[1]
8-Hydroxyefavirenz (10 μM; 3-24 h) 激活 JNK 并使磷酸化的 JNK 占总 JNK 的比例增加 4.2 倍。8-Hydroxyefavirenz 增加 BimEL mRNA 和蛋白表达[1]

Cell Viability Assay[1]

Cell Line:Primary human hepatocytes
Concentration:1 and 10 μM
Incubation Time:3, 6, 12 and 24 hours
Result:Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h.

Western Blot Analysis[1]

Cell Line:Primary human hepatocytes
Concentration:1 and 10 μM
Incubation Time:3, 6, 12 and 24 hours
Result:Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line:Primary human hepatocytes
Concentration:1 and 10 μM
Incubation Time:3, 6, 12 and 24 hours
Result:Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL.
分子量

331.67

Formula

C14H9ClF3NO3

CAS 号

205754-33-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.