MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor ofp38αMAPKwith aK_iof 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenousp38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia^[1].

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia^[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC₅₀values are 332 nM and 936 nM for MK2 and IL-1β, respectively^[1].

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; oral daily for 3–4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests^[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP^NLh/NLh× PS^P264L/P264Lknock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice^[1].

417.93

C₂₄H₂₄ClN₅

1923773-01-6

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Please store the product under the recommended conditions in the Certificate of Analysis.