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MW-150 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MW-150 hydrochloride图片
CAS NO:1923773-01-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
MW01-18-150SRM hydrochloride
产品介绍
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) 是一种选择性,具有口服活性的,可透过神经系统的p38α MAPK的抑制剂,Ki值为 101 nM。MW-150 hydrochloride (MW01-18-150SRM hydrochloride) 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
生物活性

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor ofp38αMAPKwith aKiof 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenousp38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].

IC50& Target

p38α

101 nM (Ki)

体外研究
(In Vitro)

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

体内研究
(In Vivo)

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; oral daily for 3–4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh× PSP264L/P264Lknock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Animal Model:APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]
Dosage:2.5 mg/kg
Administration:Oral daily; 3-4 months (until cognitive impairment is present)
Result:Improved the Tg mice performance in both cognitive tests.
Clinical Trial
分子量

417.93

Formula

C24H24ClN5

CAS 号

1923773-01-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.