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B-Raf IN 10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
B-Raf IN 10图片
CAS NO:1425485-87-5
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
B-Raf IN 10 (Compound C09) 是一种BRAF抑制剂,IC50在 50-100 nM。B-Raf IN 10 具有抗肿瘤活性。
生物活性

B-Raf IN 10 (Compound C09) is aBRAFinhibitor with anIC50between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].

IC50& Target[1]

BRAF-V600E

< 50 nM (IC50)

Braf

50-100 nM (IC50)

体外研究
(In Vitro)

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
B-Raf IN 10 shows an IC50between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1].

Cell Viability Assay[1]

Cell Line:A375, SK-MEL-28, SK-MEL-31 and CHL-1
Concentration:
Incubation Time:72 h
Result:Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
分子量

494.49

性状

Solid

Formula

C22H21F3N4O4S

CAS 号

1425485-87-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(202.23 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.0223 mL10.1114 mL20.2229 mL
5 mM0.4045 mL2.0223 mL4.0446 mL
10 mM0.2022 mL1.0111 mL2.0223 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。