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L-Ascorbic acid sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-Ascorbic acid sodium salt图片
CAS NO:134-03-2
包装与价格：
包装价格(元)
10 mM * 1 mL in Water电议
500mg电议
1 g电议
5 g电议
10 g电议

产品名称
维生素C钠
Sodium ascorbate
Sodium L-ascorbate
Vitamin C sodium salt
产品介绍
L-Ascorbic acid sodium salt (Sodium ascorbate)，一种电子供体，是一种内源性抗氧化剂。L-Ascorbic acid sodium salt 选择性抑制 Cav3.2 通道 (Cav3.2 channels)，IC50为 6.5 μM。L-Ascorbic acid sodium salt 还是一种胶原沉积促进剂和弹性生成抑制剂。
生物活性

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibitsCav3.2 channelswith anIC50of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].

IC50& Target

T-type calcium channel

 

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].

体内研究
(In Vivo)

Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5].
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].

Clinical Trial
分子量

198.11

性状

Solid

Formula

C6H7NaO6

CAS 号

134-03-2

中文名称

L-抗坏血酸钠；维生素C钠

结构分类
  • Others
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(504.77 mM;Need ultrasonic)

DMSO : 1 mg/mL(5.05 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.0477 mL25.2385 mL50.4770 mL
5 mM1.0095 mL5.0477 mL10.0954 mL
10 mM0.5048 mL2.5239 mL5.0477 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (252.39 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。