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Apoptosis Activator 2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Apoptosis Activator 2图片
CAS NO:79183-19-0
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Apoptosis Activator 2 是一种有效的细胞凋亡激活剂，以细胞 c 依赖性方式诱导 Apaf-1 寡聚化，增加 procaspase-9 加工和随后的 caspase-3 活化。
Cas No.79183-19-0
别名1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮
化学名1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Canonical SMILESC1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
分子式C15H9Cl2NO2
分子量306.1
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4μM [1].

Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. It is found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation. Moreover, this induction of apoptosis only occurs in tumor cell lines (such as breast, lung, colon, and epidermal cancer cell lines). Normal cell lines are resistant to Apoptosis Activator 2 [1, 2].

References:
[1] Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.
[2] Nguyen TV, Jayaraman A, Quaglino A, Pike CJ. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22.