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Protosappanin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protosappanin B图片
CAS NO:102036-29-3
包装:20mg
市场价:2909元

产品介绍
Protosappanin B 是一种从 Lignum Sappan 中提取的酚类化合物。抗癌活性。 Protosappanin B 在人膀胱癌细胞中诱导细胞凋亡并导致 G1 细胞周期停滞。
Cas No.102036-29-3
别名原苏木素B(原巴西苏木素),(-)-Protosappanin B
化学名7-(hydroxymethyl)-7,8-dihydro-6H-dibenzo[b,d]oxocine-3,7,10,11-tetraol
Canonical SMILESOCC(CO1)(O)CC2=CC(O)=C(O)C=C2C3=C1C=C(O)C=C3
分子式C16H16O6
分子量304.09
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2].

Protosappanin B (12.5, 25, 50, 100, 200 μg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 μg/mL, 26.73 μg/mL, and 76.53 μg/mL for SW-480, HCT-116, and BTT cells, respectively[1].

References:
[1]. Yang X, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan. Integr Cancer Ther. 2016 Mar;15(1):87-95.
[2]. Yang X, et al. Protosappanin B promotes apoptosis and causes G1 cell cycle arrest in human bladder cancer cells. Sci Rep. 2019 Jan 31;9(1):1048.