Glyburide-d11 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K⁺channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity^[1]. Glibenclamide inhibitsP-glycoprotein. Glibenclamide directly binds and blocks theSUR1subunits ofK_ATPand inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)^[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability^[4]. Glibenclamide can induceautophagy^[5].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

505.07

C₂₃H₁₇D₁₁ClN₃O₅S

1189985-02-1

格列本脲 d11

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.