Ivacaftor-d19 (VX-770-d19) is the deuterium labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailableCFTRpotentiator, targeting G551D-CFTR and F508del-CFTR withEC₅₀s of 100 nM and 25 nM, respectively^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

411.61

C₂₄H₉D₁₉N₂O₃

1413431-22-7

依伐卡托 D19

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.