NS1652 is a reversibleanion conductanceinhibitor, blockschloride channel, with anIC₅₀of 1.6 μM in human and mouse red blood cells.

IC50: 1.6 μM (chloride channel, human and mouse red blood cell)^[1]

NS1652 potently inhibits the chloride conductance (IC₅₀, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC₅₀, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production with an IC₅₀of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells^[1]. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl^-conductance^[2].

NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl^-conductance by >90% in mice^[2].

324.25

Solid

C₁₅H₁₁F₃N₂O₃

1566-81-0

Room temperature in continental US; may vary elsewhere.

DMSO : 5 mg/mL(15.42 mM;Need ultrasonic)

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