CAS NO: | 608510-47-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Pactimibe sulfate (CS-505) is a dualACAT1/2inhibitor withIC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibitsACATwithIC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibitsoleoyl-CoAwith aKivalue of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibitscholesteryl ester formationwith anIC50of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasmacholesterolactivity[2]. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | Pactimibe sulfate (CS-505) induces moderate ACAT inhibition in monocyte-derived macrophages, leading to the suppression of foam cell formation[2]. | ||||||||||||||||
体内研究 (In Vivo) | Pactimibe sulfate (CS-505; 60 and 200 mg/kg/day; oral gavage; twice a day; 12 weeks) induces an inhibition for ACAT-1 and ACAT-2, causing a reduction of plasma cholesterol but no influence on macrophage- or collagen-positive areas[3].
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Clinical Trial | |||||||||||||||||
分子量 | 465.65 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H40N2O3.1/2H2O4S | ||||||||||||||||
CAS 号 | 608510-47-0 | ||||||||||||||||
中文名称 | 帕替麦布硫酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 120 mg/mL(257.70 mM;Need ultrasonic) H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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