Camalexin 是一种从 Camelina sativa (Cruciferae) 中分离出来的植物抗毒素，具有抗菌、抗真菌、抗增殖和抗癌活性。
| Cas No. | 135531-86-1 |
| 化学名 | 3-(2-thiazolyl)-1H-indole |
| Canonical SMILES | C1(C(C2=NC=CS2)=CN3)=C3C=CC=C1 |
| 分子式 | C11H8N2S |
| 分子量 | 200.3 |
| 溶解度 | DMF: 14 mg/ml,DMSO: 33 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol. |
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