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LP 44
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LP 44图片
CAS NO:824958-12-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
LP44 (hydrochloride) 是一种选择性 5-HT7 激动剂,Ki 为 0.22 nM。
Cas No.824958-12-5
化学名(R)-6-(4-(2-(methylthio)phenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrochloride
Canonical SMILESO=C(CCCCCN1CCN(C2=CC=CC=C2SC)CC1)N[C@@H]3CCCC4=CC=CC=C34.Cl
分子式C27H37N3OS.HCl
分子量488.13
溶解度10mg/mL in ethanol, or in DMSO, or in DMF
储存条件Desiccate at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LP44 is a full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively.1 It can induce relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM.[1]

Reference:
[1]. Leopoldo, M., Berardi, F., Colabufo, N.A., et al. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem 47, 6616-6624 (2004).