Enpp/Carbonic anhydrase-IN-1

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包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Enpp/Carbonic anhydrase-IN-1 (compound 1e) 是一种有效的Enpp和carbonic anhydrase抑制剂，对 NPP1、NPP2、NPP3、CA-II、CA-IX 的IC₅₀值分别 1.36、1.35、3.00、0.88、1.02 μM。Enpp/Carbonic anhydrase-IN-1 对癌细胞具有抗增殖活性，对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-1 诱导细胞凋亡 (< a href="apoptosis" target="_blank">apoptosis)。

生物活性

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potentEnppandcarbonic anhydraseinhibitor withIC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity forcancercells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces (< a href="apoptosis" target="_blank">apoptosis)^[1].

IC₅₀& Target^[1]

CA Ⅱ

0.88 μM (IC₅₀)

CA Ⅸ

1.02 μM (IC₅₀)

NPP1

1.36 μM (IC₅₀)

NPP2

1.35 μM (IC₅₀)

NPP3

3.00 μM (IC₅₀)

体外研究
(In Vitro)

Enpp/Carbonic anhydrase-IN-1 (compound 1e) (0-100 μM; ) 抑制癌细胞生长，对 K-562、RPMI-8226、SR、COLO 205、HT-29、SF-539 细胞的 IC₅₀值分别为 0.32、0.40、0.58、0.87、0.40、0.96 μM^[1].
Enpp/Carbonic anhydrase-IN-1 (0-2 μM) 对正常乳腺上皮细胞 (HME1) 和正常皮肤成纤维细胞 (F180) 显示低细胞毒性，IC₅₀值均大于 50 μM^[1].
Enpp/Carbonic anhydrase-IN-1 (0.32, 0.64 μM) 以剂量依赖的方式诱导 K-562 细胞凋亡^[1]。

Cell Proliferation Assay^[1]

Cell Line:	K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells
Concentration:	0-100 μM
Incubation Time:
Result:	Inhibited the cell growth with IC₅₀s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 μM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively.

Apoptosis Analysis^[1]

Cell Line:	K-562 cells
Concentration:	0.32, 0.64 μM
Incubation Time:
Result:	Induced apoptosis in a dose-dependent manner.

分子量

411.51

Formula

C₂₃H₂₅NO₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.