AZD4694

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AZD4694

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1054629-49-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

NAV4694

产品介绍

AZD4694 (NAV4694) 是一种氟化 β-淀粉样蛋白 (Aβ) 斑块神经成像的 PET 放射配基，对Aβ纤维具有高度亲和力 (K_d= 2.3 nM)。

生物活性

AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity forAβ fibrils(K_d= 2.3 nM)^[1].

IC₅₀& Target

Kd: 2.3 nM (Aβ)

体内研究
(In Vivo)

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue^[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [³H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients^[1].

Animal Model:	Male Sprague–Dawley rats (275-300 g)^[1]
Dosage:	4 mL/kg
Administration:	I.v.
Result:	Inhibited [³H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.

Clinical Trial

分子量

258.25

Formula

C₁₄H₁₁FN₂O₂

CAS 号

1054629-49-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.