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Itopride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Itopride图片
CAS NO:122898-67-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
HSR803 free base
产品介绍
Itopride (HSR803 free base) 是一种口服有效的多巴胺 2 (dopamine-2)拮抗剂和乙酰胆碱酯酶 (AChE)抑制剂。Itopride 通过抗多巴胺能和抗乙酰胆碱酯作用增强胃动力,可用作胃肠促动力剂。Itopride 可用于胃食管返流疾病 (GERD) 的研究。
生物活性

Itopride (HSR803 free base) is a potent and orally activedopamine-2antagonist and anacetylcholine esterase (AChE)inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1].

IC50& Target[1]

AChE

 

D2Receptor

 

体外研究
(In Vitro)

Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3].
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3].

体内研究
(In Vivo)

Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group[4].
Itopride (30 mg/kg; p.o.) displays Cmaxof 358 ‰, T1/2of 24.9 min[4].

Clinical Trial
分子量

358.43

Formula

C20H26N2O4

CAS 号

122898-67-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.