Itopride (HSR803 free base) is a potent and orally activedopamine-2antagonist and anacetylcholine esterase (AChE)inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)^[1].

Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor^[3].
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum^[3].

Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group^[4].
Itopride (30 mg/kg; p.o.) displays C_maxof 358 ‰, T_1/2of 24.9 min^[4].

358.43

C₂₀H₂₆N₂O₄

122898-67-3

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Please store the product under the recommended conditions in the Certificate of Analysis.