Physostigmine hemisulfate

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CAS NO:

64-47-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

毒扁豆碱半硫酸盐
Eserine hemisulfate

产品介绍

Physostigmine hemisulfate (Eserine hemisulfate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine hemisulfate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine hemisulfate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine hemisulfate 也是抗胆碱能中毒的解毒剂。

生物活性

Physostigmine hemisulfate (Eserine hemisulfate) is a reversibleacetylcholinesterase (AChE)inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning^[1]^[2]^[3]^[4].

体内研究
(In Vivo)

Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice^[2].
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats^[4].

Animal Model:	Heterozygous transgenic mice (Tg(+) mice)^[2]
Dosage:	0.03, 0.1, and 0.3 mg/kg
Administration:	SC; daily for 6 weeks
Result:	Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.

Clinical Trial

分子量

324.38

Formula

C₁₅H₂₁N₃O₂.1/2H₂O₄S

CAS 号

64-47-1

中文名称

毒扁豆碱半硫酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.