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Physostigmine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Physostigmine图片
CAS NO:57-47-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
毒扁豆碱
Eserine
产品介绍
Physostigmine (Eserine) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine 也是抗胆碱能中毒的解毒剂。
生物活性

Physostigmine (Eserine) is a reversibleacetylcholinesterase (AChE)inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

体内研究
(In Vivo)

Physostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].
Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4].

Animal Model:Heterozygous transgenic mice (Tg(+) mice)[2]
Dosage:0.03, 0.1, and 0.3 mg/kg
Administration:SC; daily for 6 weeks
Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Clinical Trial
分子量

275.35

Formula

C15H21N3O2

CAS 号

57-47-6

中文名称

毒扁豆碱;依色林;卡拉巴豆碱

结构分类
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • Leguminosae
  • Lablab purpureus (L.) Sweet
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.