Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands withIC₅₀s of 8.05, 9.83 and 0.57 μM forhMAO-B,NRF2andQR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasingROSproduction in okadaic acid-treated mice hippocampal slices^[1].

IC₅₀: 8.05 μM (hMAO-B), 9.83 μM (NRF2), 0.57 μM (QR2)^[1]

Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%^[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (OA)) significantly increases the cell viability of OA-treated rat primary cortical neurons to 70-80%^[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (10 μM) shows the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), as well as the greatest distance of cell migration in mice NSCs which isolated from SGZ^[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 72 hours) confers neuroprotection and reduces cell death, decreasing ROS production in mice hippocampal slices exposed to OA^[1].

256.26

C₁₄H₁₂N₂O₃

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