EUK-134 是一种合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。EUK-134 是一种具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。EUK-134 是一种保护有丝分裂的抗氧化剂。EUK-134 作用于 H9C2 细胞，降低NF-κB表达、MDA 水平和蛋白质羰基化。
| 生物活性 | EUK-134, a syntheticsuperoxide dismutaseand catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression ofNF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3]. |
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体外研究
(In Vitro) | EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2].
Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2].
EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3].
Cell Viability Assay[2] | Cell Line: | NRK-52E cells | | Concentration: | 0, 1, 3, 10, 30, 100, and 300 μM | | Incubation Time: | 24 hours | | Result: | Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| 溶解性数据 | In Vitro: H2O : 10 mg/mL(24.00 mM;ultrasonic and warming and heat to 80℃) 配制储备液 | 1 mM | 2.3996 mL | 11.9979 mL | 23.9958 mL | | 5 mM | 0.4799 mL | 2.3996 mL | 4.7992 mL | | 10 mM | 0.2400 mL | 1.1998 mL | 2.3996 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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