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DEPMPO
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DEPMPO图片
CAS NO:157230-67-6
包装与价格：
包装价格(元)
50mg电议
250mg电议
500mg电议

产品介绍
cDEPMPO 是一种有效的抗癌前药。高浓度的 DEPMPO 自旋捕获 .OH 自由基以及由单电子还原的 BTO（苯并三嗪 1,4-二-N-氧化物）化合物产生的芳基自由基。
Cas No.157230-67-6
别名5-(二乙氧基磷酰)-5-甲基-1-吡咯啉-N-氧化物,5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
化学名P-(3,4-dihydro-2-methyl-1-oxido-2H-pyrrol-2-yl)-phosphonic acid, diethyl ester
Canonical SMILES[O-][N+]1=CCCC1(P(OCC)(OCC)=O)C
分子式C9H18NO4P
分子量235.2
溶解度Soluble in water to 100 mM, in ethanol and in DMSO to 25 mM
储存条件Store at -80℃,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. [1] [2] [3] DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.[3] A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2o- does not produce the OHo adduct, which can be a drawback when using DMPO. [2][3]

Reference:
[1]. Khan, N., Wilmont, C.M., Rosen, G.M., et al. Spin traps: In vitro toxicity and stability of radical adducts. Free Radical Biology & Medicine 34(11), 1473-1481 (2003).
[2]. Anzai, K., Aikawa, T., Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. Archives of Biochemistry and Biophysics 415, 251-256 (2003).
[3]. Liu, K.J., Miyake, M., Panz, T., et al. Evaluation of DEPMPO as a spin trapping agent in biological systems. Free Radical Biology & Medicine 26, 714-721 (1999).