| CAS NO: | 479-18-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 254.24 |
|---|---|
| Formula | C10H14N4O4 |
| CAS No. | 479-18-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 51 mg/mL (200.6 mM) |
| Water:<1 mg/mL | |
| Ethanol: 51 mg/mL (200.6 mM) | |
| Solubility (In vivo) | Chemical Name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione InChi Key: KSCFJBIXMNOVSH-UHFFFAOYSA-N InChi Code: InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 SMILES Code: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O |
| Synonyms | Diprophylline; Dyphylline; Lufyllin; Corphyllin; Neothylline |
| In Vitro | In vitro activity: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | [1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21. [2]. Iancu L, et al. Trials with xanthine derivatives in systemic treatment of psoriasis. Dermatologica. 1979;159(1):55-61. |
m.cnreagent.com