BMS-8 抑制 PD-1/PD-L1 相互作用，IC50 为 7.2 μM. BMS-8 直接与 PD-L1 结合并诱导 PD-L1 同源二聚体的形成，从而阻止与 PD-1 的相互作用。
| Cas No. | 1675201-90-7 |
| Canonical SMILES | CC1=C(COC2=CC=C(CN3CCCCC3C(O)=O)C=C2Br)C=CC=C1C4=CC=CC=C4 |
| 分子式 | C27H28BrNO3 |
| 分子量 | 494.4 |
| 溶解度 | Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BMS-8 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay. |
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