PI3K/mTOR Inhibitor-8

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2492376-85-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI3K/mTOR Inhibitor-8 (Compound 18b) 是一种PI3K和mTOR双重抑制剂，对PI3Kα和 mTOR 的IC₅₀分别为 0.46 nM 和 12 nM。PI3K/mTOR Inhibitor-8 诱导 HCT-116 细胞凋亡 (apoptosis)，在 G1/S 期阻滞细胞周期。

生物活性

PI3K/mTOR Inhibitor-8 (Compound 18b) is aPI3KandmTORdual inhibitor withIC₅₀values of 0.46 nM and 12 nM againstPI3KαandmTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cellsapoptosisand arrests cell cycle at the G1/S phase^[1].

IC₅₀& Target

PI3Kα

0.46 nM (IC₅₀)

mTOR

12 nM (IC₅₀)

体外研究
(In Vitro)

PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC₅₀values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively^[1].

分子量

506.54

Formula

C₂₃H₂₂N₈O₄S

CAS 号

2492376-85-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.